Amphiphilic Poly(dimethylsiloxane-ethylene-propylene oxide)-polyisocyanurate Cross-Linked Block Copolymers in a Membrane Gas Separation

Structural Polymorphism of Poly(ethylene oxide)-Poly(propylene oxide) Block Copolymers in Nonaqueous Polar Solvents

The solution properties of water-soluble amphiphiles in nonaqueous polar solvents are important in the elucidation of the effects of solvent quality on self-assembly and also in practical applications where the use of water as a solvent is undesirable. We studied the self-assembly of a poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) block copolymer (Pluronic P105: EO37PO58EO37) in formamid...

Amphiphilic, tri-block copolymers provide potent membrane-targeted neuroprotection.

Excitatory amino acid receptor activation and reactive oxygen species production are important mediators of neuronal death following acute brain injury and can lead to loss of membrane integrity. Poloxamer 188 (P188) is an amphiphilic, polyethylenepolypropylene-polyethylene copolymer that restores plasma membrane integrity of nonneuronal cells following membrane injury. Here, we demonstrate tha...

Hybrid materials from amphiphilic block copolymers and membrane proteins.

Self-assembly of reactive amphiphilic block copolymers is used to prepare nanostructured hydrogels with exceptional permeability properties, vesicular structures and planar, freestanding membranes in aqueous solution. Although the underlying block copolymer membranes are two-three-fold thicker than conventional lipid bilayers, they can be regarded as mimetic of biological membranes and can be u...

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Amphiphilic poly(ethylene oxide)–poly(propylene oxide) (PEO–PPO)-based copolymers are thermoresponsive materials having aggregation properties in aqueous medium. As hydrosolubilizers of poorly water-soluble drugs and improved stability of sensitive agents, these materials have been investigated for improvement in solubility, stability, release and bioavailability of drugs. The goal of the prese...

Intracellular delivery of VEGF165 encoding gene therapeutic using trifunctional copolymers of ethylene oxide and propylene oxide